中文

|| About

DEGRON THERAPEUTICS

Degron Therapeutics is discovering and developing a new class of targeted protein degradation therapeutics small molecule molecular glue degrader (MGD) drugs. Degron has assembled a team of world-class scientific leaders and industry veterans, bringing its in-depth knowledge in the MGD space to the identification and validation of new MGD targets, particularly those disease drivers but undruggable or insufficiently drugged by other modalities, and to the discovery of novel selective MGD compounds to address unmet medical needs in all therapeutic areas.

  • The problem

    In the past, MGDs have been discovered serendipitously. The rational design of MGDs has been extremely challenging due to the complexity of ternary structure formed by E3 ligase-MGD-target Until now.

  • Our approach

    Differentiated GlueXplorer™ MGD discovery platform enabled by:
    - Proprietary and structurally differentiated glue library with 10,000 compounds
    - Multiple complementary screening and validation platforms
    - Large data sets for AI/Machine Learning

  • Our results

    To date, Degron has developed a robust and differentiated pipeline of First-in-Class MGDs for important disease targets.

2021

2021

Founded in 2021
Robust MGD discovery platform

$34.5M

$34.5M

Capital raised: $34.5 million

10,000+

10,000+

Compounds in structurally differentiated MGD
library: >10,000 compounds

9

9

Neo-glue targets validated: 9

INNOVATION
INNOVATION


Dedicate to the research and clinical development of novel molecular glue degraders
Differentiated GlueXplorerTM Platform

Collaboration Opportunities

Partnership based on the demands

Learn more

01

Global leading drug discovery platform for novel molecular glue degraders

02

Efficient identification and validation of disease-specific targets

03

Targeting undruggable targets that are difficult to drug via traditional approaches; novel targets and first-in-class compounds

04

Available for all therapeutic areas; global and regional out-license

MORE

NEWS

NEWS

MORE

Contact us